Understanding GIP/GLP-1: The Science Behind GIP/GLP-1 Agonists and Their Mechanism

What Are GLP-1 and GIP/GLP-1 Agonists & How Do They Work?

You’ve probably heard of GIP/GLP-1 drugs, they’re getting a lot of attention for their role in weight management. But what exactly are GIP/GLP-1 hormones, and how do they work in the body?

Understanding GIP and GLP-1

GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) are naturally occurring hormones called incretins. They’re released by the gut after eating and help regulate how the body handles food, influencing appetite, digestion, and energy use.

GLP-1 slows stomach emptying and signals the brain’s appetite centres to help one feel full sooner. GIP also supports this process by working alongside GLP-1 to enhance the body’s response to food intake.

How GLP-1 and GIP/GLP-1 Agonists Work

GLP-1 receptor agonists are medications that mimic the natural GLP-1 hormone. They bind to the same receptors in the brain and gut, helping reduce appetite and food intake.

Dual GIP/GLP-1 agonists, like tirzepatide, activate both incretin pathways simultaneously. Research suggests this may lead to greater effects on appetite regulation and body weight compared to targeting GLP-1 alone, though responses vary from person to person.

These medications are typically given by injection or oral tablet and are used under medical supervision as part of a comprehensive weight management plan that includes nutrition and activity changes.

Key Takeaway

GLP-1 and GIP/GLP-1 agonists work by supporting the body’s natural satiety signals, helping people eat less and manage their weight more effectively. They’re not quick fixes but tools that, when paired with healthy habits, may aid in sustainable weight management.